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Case of the Month - February

17-year-old female patient. Alteration in short-term memory. Occipital headache.

Patient underwent minimally invasive resection with a transcortical tubular brain retractor under a microscope.

Post-operative image with subtotal resection of the lesion, small 2 cm craniotomy.

Primary Primary Neuroectodermal Tumors of the Central Nervous System

• They represent only 2.5% of brain tumors in children.

• The prognosis is worse in children  even that Medulloblastomas

• From undifferentiated neuroepithelial cells

• Diagnosis is by histology and immunohistochemistry

• There is no treatment algorithm created yet.

• Usually: Biopsy, Maximum Safe Resection, QT and RT.

• Personalized QT: Vincristine, Cisplatin, Carboplatin, Methotrexate (High doses).

• Stage, Age, etc.

• 5-year survival <50% in all patient groups.



  1. Visee S, Soltner C, Rialland X, Machet MC, Loussouarn D, Milinkevitch S, et al. Supratentorial primitive neuroecto- dermal tumors of the brain: multidirectional differentiation does not in uence prognosis. A clinicopathological report of 18 patients. Histopathology 2005; 46: 403-12. 

  2. Lester RA, Brown LC, Eckel LJ, et al. Clinical outcomes of children and adults with central nervous system primitive neuroectodermal tumor. J Neurooncol (2014) 120: 371–379 

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