Neurosurgery Service
San José University Children's Hospital (HIUSJ)
Hospital de San José (HSJ) - Bogotá Surgery Society
University Foundation of Health Sciences (FUCS)
Case of the Month - February
17-year-old female patient. Alteration in short-term memory. Occipital headache.
Patient underwent minimally invasive resection with a transcortical tubular brain retractor under a microscope.
Post-operative image with subtotal resection of the lesion, small 2 cm craniotomy.
Primary Primary Neuroectodermal Tumors of the Central Nervous System
• They represent only 2.5% of brain tumors in children.
• The prognosis is worse in children even that Medulloblastomas
• From undifferentiated neuroepithelial cells
• Diagnosis is by histology and immunohistochemistry
• There is no treatment algorithm created yet.
• Usually: Biopsy, Maximum Safe Resection, QT and RT.
• Personalized QT: Vincristine, Cisplatin, Carboplatin, Methotrexate (High doses).
• Stage, Age, etc.
• 5-year survival <50% in all patient groups.
References
Visee S, Soltner C, Rialland X, Machet MC, Loussouarn D, Milinkevitch S, et al. Supratentorial primitive neuroecto- dermal tumors of the brain: multidirectional differentiation does not in uence prognosis. A clinicopathological report of 18 patients. Histopathology 2005; 46: 403-12.
Lester RA, Brown LC, Eckel LJ, et al. Clinical outcomes of children and adults with central nervous system primitive neuroectodermal tumor. J Neurooncol (2014) 120: 371–379